USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P4HA1_HUMAN USC-OGP 2-DE database:  P4HA1_HUMAN P4HA1_HUMAN General information about the entry View entry in simple text format Entry name P4HA1_HUMAN Primary accession number P13674 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Prolyl 4-hydroxylase subunit alpha-1; Short=4-PH alpha-1; EC=1.14.11.2; AltName: Full=Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; Flags: Precursor;. Gene name Name=P4HA1 Synonyms=P4HA Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1138: pI=5.84; Mw=62554 Cross-references UniProtKB/Swiss-Prot P13674; P4HA1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name P4HA1_HUMAN Primary accession number P13674 Secondary accession number(s) C9JL12 Q15082 Q15083 Q5VSQ5 Sequence was last modified on  November 1, 1997 (version 2) Annotations were last modified on  February 15, 2017 (version 191) Name and origin of the protein Description RecName: Full=Prolyl 4-hydroxylase subunit alpha-1; Short=4-PH alpha-1; EC=1.14.11.2; AltName: Full=Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; Flags: Precursor; Gene name Name=P4HA1 Synonyms=P4HA Encoded on Name=P4HA1; Synonyms=P4HA Keywords 3D-structure; Alternative splicing; Complete proteome; Dioxygenase; Endoplasmic reticulum; Glycoprotein; Iron; Metal-binding; Oxidoreductase; Reference proteome; Signal; TPR repeat; Vitamin C. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M24486; AAA36534.1; -; mRNA EMBL M24487; AAA36535.1; -; mRNA EMBL U14620; AAA59068.1; -; Genomic_DNA EMBL U14607; AAA59068.1; JOINED; Genomic_DNA EMBL U14605; AAA59068.1; JOINED; Genomic_DNA EMBL U14608; AAA59068.1; JOINED; Genomic_DNA EMBL U14609; AAA59068.1; JOINED; Genomic_DNA EMBL U14611; AAA59068.1; JOINED; Genomic_DNA EMBL U14610; AAA59068.1; JOINED; Genomic_DNA EMBL U14612; AAA59068.1; JOINED; Genomic_DNA EMBL U14614; AAA59068.1; JOINED; Genomic_DNA EMBL U14615; AAA59068.1; JOINED; Genomic_DNA EMBL U14616; AAA59068.1; JOINED; Genomic_DNA EMBL U14617; AAA59068.1; JOINED; Genomic_DNA EMBL U14618; AAA59068.1; JOINED; Genomic_DNA EMBL U14619; AAA59068.1; JOINED; Genomic_DNA EMBL U14620; AAA59069.1; -; Genomic_DNA EMBL U14607; AAA59069.1; JOINED; Genomic_DNA EMBL U14605; AAA59069.1; JOINED; Genomic_DNA EMBL U14608; AAA59069.1; JOINED; Genomic_DNA EMBL U14609; AAA59069.1; JOINED; Genomic_DNA EMBL U14611; AAA59069.1; JOINED; Genomic_DNA EMBL U14610; AAA59069.1; JOINED; Genomic_DNA EMBL U14612; AAA59069.1; JOINED; Genomic_DNA EMBL U14613; AAA59069.1; JOINED; Genomic_DNA EMBL U14615; AAA59069.1; JOINED; Genomic_DNA EMBL U14616; AAA59069.1; JOINED; Genomic_DNA EMBL U14617; AAA59069.1; JOINED; Genomic_DNA EMBL U14618; AAA59069.1; JOINED; Genomic_DNA EMBL U14619; AAA59069.1; JOINED; Genomic_DNA EMBL CD013929; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AL731563; CAH72754.1; -; Genomic_DNA EMBL BC034998; AAH34998.1; -; mRNA CCDS CCDS41537.1; -. [P13674-1]; . CCDS CCDS44432.1; -. [P13674-3]; . CCDS CCDS7320.1; -. [P13674-2]; . PIR A33919; DAHUA1; . PIR I37173; DAHUA2; . RefSeq NP_000908.2; NM_000917.3. [P13674-2]; . RefSeq NP_001017962.1; NM_001017962.2. [P13674-1]; . RefSeq NP_001136067.1; NM_001142595.1. [P13674-1]; . RefSeq NP_001136068.1; NM_001142596.1. [P13674-3]; . UniGene Hs.500047; -; . UniGene Hs.593005; -; . PDB 1TJC; X-ray; 2.30 A; A/B=161-261 PDB 2V5F; X-ray; 2.03 A; A=161-263 PDB 2YQ8; X-ray; 2.99 A; A/B=18-255 PDB 4BT8; X-ray; 2.20 A; A/B=18-255 PDB 4BT9; X-ray; 1.90 A; A/B=18-255 PDB 4BTA; X-ray; 2.95 A; A/B=18-261 PDB 4BTB; X-ray; 1.90 A; A=18-255 PDBsum 1TJC; -; . PDBsum 2V5F; -; . PDBsum 2YQ8; -; . PDBsum 4BT8; -; . PDBsum 4BT9; -; . PDBsum 4BTA; -; . PDBsum 4BTB; -; . ProteinModelPortal P13674; -; . SMR P13674; -; . BioGrid 111072; 40; . DIP DIP-38180N; -; . IntAct P13674; 45; . MINT MINT-4657265; -; . STRING 9606.ENSP00000263556; -; . ChEMBL CHEMBL1250350; -; . DrugBank DB01275; Hydralazine; . DrugBank DB00172; L-Proline; . DrugBank DB00139; Succinic acid; . DrugBank DB00126; Vitamin C; . iPTMnet P13674; -; . PhosphoSitePlus P13674; -; . SwissPalm P13674; -; . BioMuta P4HA1; -; . DMDM 2507090; -; . EPD P13674; -; . MaxQB P13674; -; . PaxDb P13674; -; . PeptideAtlas P13674; -; . PRIDE P13674; -; . DNASU 5033; -; . Ensembl ENST00000263556; ENSP00000263556; ENSG00000122884. [P13674-2]; . Ensembl ENST00000307116; ENSP00000307318; ENSG00000122884. [P13674-1]; . Ensembl ENST00000373008; ENSP00000362099; ENSG00000122884. [P13674-2]; . Ensembl ENST00000394890; ENSP00000378353; ENSG00000122884. [P13674-1]; . Ensembl ENST00000440381; ENSP00000414464; ENSG00000122884. [P13674-3]; . GeneID 5033; -; . KEGG hsa:5033; -; . UCSC uc001jtg.4; human. [P13674-1]; . CTD 5033; -; . DisGeNET 5033; -; . GeneCards P4HA1; -; . HGNC HGNC:8546; P4HA1; . HPA HPA007599; -; . HPA HPA026593; -; . MIM 176710; gene; . neXtProt NX_P13674; -; . OpenTargets ENSG00000122884; -; . PharmGKB PA32874; -; . eggNOG KOG1591; Eukaryota; . eggNOG ENOG410XS5J; LUCA; . GeneTree ENSGT00390000018885; -; . HOGENOM HOG000230465; -; . HOVERGEN HBG006834; -; . InParanoid P13674; -; . KO K00472; -; . OMA FLTVEDC; -; . PhylomeDB P13674; -; . TreeFam TF313393; -; . BRENDA 1.14.11.2; 2681; . Reactome R-HSA-1650814; Collagen biosynthesis and modifying enzymes; . EvolutionaryTrace P13674; -; . GeneWiki P4HA1; -; . GenomeRNAi 5033; -; . PRO PR:P13674; -; . Proteomes UP000005640; Chromosome 10; . Bgee ENSG00000122884; -; . CleanEx HS_P4HA1; -; . ExpressionAtlas P13674; baseline and differential; . Genevisible P13674; HS; . GO GO:0005783; C:endoplasmic reticulum; IDA:HPA; . GO GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IDA:HPA; . GO GO:0016222; C:procollagen-proline 4-dioxygenase complex; IEA:Ensembl; . GO GO:0005506; F:iron ion binding; IEA:InterPro; . GO GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW; . GO GO:0016702; F:oxidoreductase activity; acting on single donors with incorporation of molecular oxygen; incorporation of two atoms of oxygen IEA:InterPro . GO GO:0004656; F:procollagen-proline 4-dioxygenase activity; TAS:ProtInc; . GO GO:0030199; P:collagen fibril organization; IEA:Ensembl; . GO GO:0018401; P:peptidyl-proline hydroxylation to 4-hydroxy-L-proline; IEA:Ensembl; . Gene3D 1.25.40.10; -; 2; . InterPro IPR005123; Oxoglu/Fe-dep_dioxygenase; . InterPro IPR006620; Pro_4_hyd_alph; . InterPro IPR013547; Pro_4_hyd_alph_N; . InterPro IPR013026; TPR-contain_dom; . InterPro IPR011990; TPR-like_helical_dom; . InterPro IPR019734; TPR_repeat; . Pfam PF13640; 2OG-FeII_Oxy_3; 1; . Pfam PF08336; P4Ha_N; 1; . SMART SM00702; P4Hc; 1; . SUPFAM SSF48452; SSF48452; 1; . PROSITE PS51471; FE2OG_OXY; 1; . PROSITE PS50005; TPR; 1; . PROSITE PS50293; TPR_REGION; 1; .

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